Alzheimer s Disease The Most Widespread Age Related...

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most widespread age-related neurodegenerative diseases. Both diseases impact a considerable number of people, where AD occurs in around 10 percent of the population greater than the age of 65 while PD occurs in roughly 1 percent of the population above the age of 65. AD is considered to be the most widespread cause of dementia, characterised by the progressive memory and cognitive deficits which impair ones day to day activities. The pathological hallmark of AD comprises of extracellular accumulation of senile plaques consisting of mainly amyloid-beta (AÃŽ ²) peptides, along with neurofibrillary tangles which are composed of the phosphorylated tau protein, located in the hippocampus and cortex. Conversely, PD is considered to be the most widespread movement disorder that is characterised by symptoms such as rigidity slow movements, resting tremor and other instabilities. The extreme loss of dopaminergic neuro nes in the substantia nigra is what defines PD, as the loss of this nerve cell can be linked to Lewy bodies containing aggregates of a soluble protein called ÃŽ ±-synuclein. The aggregation of prion proteins and their transmissibility from one cell to another has been shown to be evident (Cushman et al.; Goedert et al. 2010), therefore strongly suggesting that these events may play a role in pathogenesis for many diseases, including both AD and PD. While none of these diseases is infectious in an identical way asShow MoreRelatedAlzheimer s Disease : A Progressive And Neurodegenerative Form Of Dementia2437 Words   |  10 PagesAlzheimer’s Disease (AD) is a progressive and neurodegenerative form of dementia that causes problems with memory, thinking, reasoning, judgement and decision-making, recognizing, as well as behavior, and is serious enough to interfere with daily life and activities, that eventually leads to profound physical as well as mental disabilities, resulting in the need for institutional care (Hoyer Roodin, 2009). AD is most widespread in senior population aged 65 and over, which constitutes approximatelyRead MoreShould Marijuana Be Legalized?1457 Words   |  6 PagesUnited State’s economy and provide a medicine that is available for those in need. Marijuana has been a part of our history ever since the 1600’s. When the colony of Jamestown was established in Virginia, one of the laws enacted by King James I demanded that all farmers grow Indian hempseed. Hemp is a part of the marijuana plant and is one of the most strongest and durable of all natural fibers. Over the next couple centuries, many other laws were passed ordering even more hemp to be grown. InRead MoreBrain Structure And Basic Functions6760 Words   |  28 Pagesconcentration/focus - Concentration/Focus Disorders IV- Brain Nutrition V- Brain Sleep VI- Brain Exercise VII- Brain Social Life VIII- Negatives for brain health - Stress - Alcohol - Smoking - Drug Addiction - Traumatic Brain Injury - Cerebrovascular Disease â€Æ' Preface The brain is the control center of the body. It controls the conscious and the unconscious body processes. It is the center for conscious thoughts and mood , allows us to make decisions , think , feel and communicate with outside . ItRead MoreGene Therapy : A Method Of Manipulating Cells At The Molecular Level2897 Words   |  12 Pagesof preventing or altering rare genetic disease states. Viruses have the natural ability to deliver genetic material to cells, which makes them excellent vectors for gene delivery (Waehler, Russell, Curiel, 2007). Lentivirus, Herpes Simplex Virus, Adenovirus and Adeno-Associated viruses (AAV) are among the most prominently used vectors for gene delivery to the therapeutic target. While, gene therapy is a promising treatment option for a range of diseases, there are still a number of unwarranted